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Gut microbiome and response to oral typhoid vaccine

We are studying the role of gut microbiome diversity on the mucosal and systemic responses to Ty21a vaccine. This is to determine if a given microbiota composition is associated with specific immune responses and to evaluate the impact of an oral typhoid vaccination on the human gut microbiota.

Headache After Lumbar Puncture Study

It is common for individuals to develop headaches after a lumbar puncture (LP) procedure. While LPs are frequently performed, little is known about the risk factors for headaches in pediatric populations. This study aims to address this gap in knowledge by evaluating the risks factors on headache incidence, duration, onset, psychological state, and impact on quality of life. This study also aims to examine health inequities.

Healthy Development

Determine how potentially stressful situations, including prematurity, hospitalizations, maternal mental health and rapid repeat births can impact a baby’s development in the first 12 months of their life.

HIGH DOSE ERYTHROPOIETIN FOR ASPHYXIA AND ENCEPHALOPATHY (HEAL)

1) To determine if 5 doses of Epo (Erythropoietin) 1000 U/kg (birth weight) intravenous (IV) reduces the rate of death or neurodevelopmental impairment (mild, moderate, or severe) at 24 months of age. 

2) To assess safety of Epo. 

3) To determine whether Epo decreases the severity of HIE-induced brain injury as evidenced by early MRI and plasma biomarkers of brain injury.

ImproveCareNow (ICN)

To improve patient care and achieve the best health outcomes possible for children with IBD.

Infant-Robot Interaction-CHLA

We are interested in observing whether and how infants learn when interacting with a robot during a learning assessment contingency paradigm. 

Influenza Breastfeeding Study

The effect of flu immunization on the level of immunity against the flu in breastmilk, and how this may help protect a breastfeeding infant.