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Leila C. Posch, MD

Medical Director, Antimicrobial Stewardship Program
Co-Director, Pediatric Transplant & Immunocompromised ID (ICID) Program
Associate Program Director, Pediatric Infectious Diseases Fellowship Program
Attending Physician, Division of Pediatric Infectious Diseases
Assistant Professor of Clinical Pediatrics, Keck School of Medicine of USC

Leila C. Posch, MD, is an Assistant Professor of Pediatrics at Keck School of Medicine of the University of Southern California, and a Pediatric Infectious Diseases (ID) Specialist at Children's Hospital Los Angeles. She serves as the Medical Director of Antimicrobial Stewardship, the Co-Director of the Transplant & Immunocompromised ID (ICID) Program, and the Associate Program Director of the CHLA Pediatric ID Fellowship Program.

After earning her Doctorate in Medicine from the University of Texas Southwestern School of Medicine, Dr. Posch completed her Pediatric Internship and Residency training at McGaw Medical Center of Northwestern University/Lurie Children’s Hospital of Chicago. She then completed her Fellowship in Pediatric Infectious Diseases at the Children’s Hospital of Philadelphia before joining the ID faculty at Children's Hospital Los Angeles in 2020.

Dr. Posch’s clinical interests are in immunocompromised and transplant ID and antimicrobial stewardship, with the goal of improving the care of some of our most vulnerable and complex patients. She has a particular interest in infections in pediatric oncology and bone marrow transplant patients. Dr. Posch’s research focuses on clinical epidemiology, quality improvement, and outcomes questions related to antimicrobial and diagnostic stewardship in vulnerable, understudied, and high-risk pediatric populations, including immunocompromised patients and surgical patients. She seeks to improve how we prevent, diagnose, and treat infections in these high-risk patients and how we mitigate side effects from medications. Dr. Posch also has a strong interest in teaching and the education of students and trainees, and she enjoys mentoring and working with learners of all levels.

Clinical Interests

Infections in Immunocompromised Host
Antimicrobial Stewardship
Prevention of Infections
Fungal Infections
Medical Education

Education

Medical School

University of Texas Southwestern Medical School

Internship

Pediatrics, McGaw Medical Center of Northwestern University/Lurie Children's Hospital of Chicago

Residency

Pediatrics, McGaw Medical Center of Northwestern University/Lurie Children's Hospital of Chicago

Fellowship

Pediatric Infectious Diseases, The Children's Hospital of Philadelphia/University of Pennsylvania

Accomplishments

Certifications

Pediatric Infectious Diseases, American Board of Pediatrics
General Pediatrics, American Board of Pediatrics

Professional Memberships

Fellow of the American Academy of Pediatrics
Member of the Pediatric Infectious Diseases Society (PIDS)
Member of the PIDS Pediatric Committee on Antimicrobial Stewardship

Publications

Posch LC, Zhu M, Robertson DM. Multipurpose care solution-induced corneal surface disruption and Pseudomonas aeruginosa internalization in the rabbit corneal epithelium. Invest Ophthalmol Vis Sci. 2014;55(7):4229-4237. doi:10.1167/iovs.14-14513.

Otto WR*, Geoghegan S*, Posch LC*, et al. The Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2 in a Pediatric Healthcare Network in the United States. J Pediatric Infect Dis Soc. 9(5):523-529, 2020. doi:10.1093/jpids/piaa074. *Otto, Geoghegan, & Posch are co-first authors

Newman AM, Posch LC, Gianchetti L, et al. Live virus vaccination following pediatric liver transplantation: Outcomes from two academic children's hospitals. Am J Transplant. 2022;22(4):1201-1212. doi:10.1111/ajt.16937

Bihm D, Huang J, Yi B, Posch L, Brown D, Lai KC. Safety of Tocilizumab and Remdesivir in Treating COVID-19 Pneumonia in Premature Twins. Pediatrics. 2023;151(4):e2022058196. doi:10.1542/peds.2022-058196.

Doan A, Huang HKT, Hadar AJ, Malvar J, Rushing T, Raca G, Kovach AE, Freyer DR, Parekh C, Stokke J, Posch LC, Dao J, Bhojwani D, Gaynon P, Orgel E. Efficacy and safety of FLAG-IDA as front-line therapy in de novo paediatric acute myeloid leukaemia population. Br J Haematol. 2023;202(1):e3-e6. doi:10.1111/bjh.18844.