Mimi Kim, MD, MSc

Co-Director, Congenital Adrenal Hyperplasia Clinic

Investigator, Endocrinology, Diabetes and Metabolism

Attending Physician

Associate Professor of Clinical Pediatrics, Keck School of Medicine of USC

Clinical Interests

Obesity, Adrenal Disorders - Congenital Adrenal Hyperplasia

Education

Medical School

Dartmouth Medical School

Residency

RUSH Medical Center

Fellowship

Research Pediatric Endocrinology Fellowship - Montreal Children's Hospital, McGill University (2004-2005); Clinical Pediatric Endocrinology Fellowship - Hasbro Children's Hospital, Brown University (2005-2008); Senior Clinical Research Fellowship - NIH Clinical Center (2008-2009)

Accomplishments

Certifications

Pediatrics and Pediatric Endocrinology: American Board of Pediatrics

Professional Memberships

Endocrine Society, Pediatric Endocrine Society, Donnell Society for Pediatric Scientists, Androgen Excess and PCOS Society, Association for Patient-Oriented Research.

Awards

CARES Foundation Pioneer Award (2018)
Top Doctors Los Angeles (2018)
The James H. Zumberge Research and Innovation Fund Individual Research Award (2015-2016)
The Saban Research Institute Innovative Pilot Award (2012-2013)
SC-CTSI KL2 Scholar (2011-2014)
The Saban Research Institute & CHLA CRACDA Awardee (2009-2011)
Women in Endocrinology Young Investigator Award (2009)

Medical & Scientific Advisory Boards

CARES Foundation (2015 - )
The Painted Turtle (2015 - )

Publications

Szymanski KM, Rink RC, Whittam B, Hensel DJ; Life with Congenital Adrenal Hyperplasia Study Group (listed as collaborator). Majority of females with a life-long experience of CAH and parents do not consider females with CAH to be intersex. J Pediatr Urol. 2020 Sep 16:S1477-5131(20)30536-2. doi: 10.1016/j.jpurol.2020.09.009. Epub ahead of print. PMID: 33041207

Richards G, Browne WV, Aydin E, Constantinescu M, Nave G, Kim MS, Watson SJ. Digit ratio (2D:4D) and congenital adrenal hyperplasia (CAH): Systematic literature review and meta-analysis. Horm Behav. 2020 Oct 6;126:104867. doi: 10.1016/j.yhbeh.2020.104867. Epub ahead of print. PMID: 32998030.

Abd-Almageed W, Mirzaalian H, Guo X, Randolph LM, Tanawattanacharoen V, Ross HM, Geffner ME, Kim MS. Assessment of Facial Morphologic Features in Patients with Congenital Adrenal Hyperplasia Using Deep Learning. JAMA Network Open. 2020;3(11):e2022199. DOI:10.1001/jamanetworkopen.2020.22199.

Kim MS, Luo S, Campbell C, Azad A, Felix K, Cabeen R, Belcher B, Kim R, Serrano-Gonzalez M, Herting MM. Prefrontal and amygdala brain morphology are associated with dietary decision-making in children and adolescents. Frontiers in Human Neuroscience – special Research Topic. DOI: 10.3389/fnhum.2020.563415. (edited)

D’Oro A, Rosoklija I, Jacobson DL, Finlayson C, Chen D, Tu DD, Austin PF, Karaviti LP, Gunn SK, Nahata L, Kapa HM, Kokorowski P, Kim MS, Messina AC, Kolon T, Yerkes EB, Cheng EY, Johnson EK. Patients’ and Caregivers’ Attitudes Toward “Disorders of Sex Development” Nomenclature. J Urol. 2020; 101097JU0000000000001076. doi:10.1097/JU.0000000000001076. PMID 32302259.

Kim MS, Koppin CM, Mohan P, Goodarzian F, Ross HM, Geffner ME, De Filippo R, Kokorowski P. Absence of Testicular Adrenal Rest Tumors in Newborns, Infants, and Toddlers with Classical Congenital Adrenal Hyperplasia. Horm Res Paediatr. 2019;92(3):157-161. doi: 10.1159/000504135. Epub 2019 Nov 20. PMID: 31747670; PMCID: PMC7004842.

Herting MM, Azad A, Kim R, Tyszka JM, Geffner ME, Kim MS. Brain Differences in the Prefrontal Cortex, Amygdala, and Hippocampus in Youth with Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab. 2020 Jan 17;. doi: 10.1210/clinem/dgaa023. [Epub ahead of print] PMID: 31950148.

Vidmar AP, Weber JF, Monzavi R, Koppin CM, Kim MS. Improved Medical-Alert ID Ownership and Utilization in Youth with Congenital Adrenal Hyperplasia Following a Parent Educational Intervention. Journal of Pediatric Endocrinology and Metabolism. 2018 Jan 26;31(2):213-219.

Kim MS, Goodarzian F, Keenan MF, Geffner ME, Koppin CM, De Filippo RE, Kokorowski PJ. Testicular Adrenal Rest Tumors in Boys and Young Adults with Congenital Adrenal Hyperplasia. Journal of Urology 2017 Mar;197(3 Pt 2):931-936.

Kim, MS; Dao-Tran, A; Davidowitz, E; Tseng, T; Gilsanz, V; Ryabets-Lienhard, A; Nguyen, E; Geffner, ME. Carotid Intima-Media Thickness Is Associated with Increased Androgens in Adolescents and Young Adults with Classical Congenital Adrenal Hyperplasia. Hormone Research in Paediatrics. 2016;85:242-249.

Press Release: Preventing Cardiovascular Disease Using Hormone Control

Kim, MS; Hu, HH; Aggabao, PC; Geffner, ME; Gilsanz, V. Presence of Brown Adipose Tissue in an Adolescent with Severe Primary Hypothyroidism. Journal of Clinical Endocrinology and Metabolism. doi 10:jc2014-1343. 2014 99(9): E1686-90.http://press.endocrine.org/doi/full/10.1210/jc.2014-1343

Kim, MS; Ryabets-Lienhard, A; Dao-Tran, A; Mittelman, SD; Gilsanz, V; Schrager, SM; Geffner, ME. Increased Abdominal Adiposity in Adolescents and Young Adults with Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. Journal of Clinical Endocrinology and Metabolism. 2015 100(8): E1153-9.

Press Release: Case Study Changes the Way We Look at Brown Fat

Hu, HH; Wu, TW; Yin, L; Kim, MS; Chia, JM; Perkins, TG; Gilsanz, V. MRI Detection of Brown Adipose Tissue with Low Fat Content in Newborns with Hypothermia. Magnetic Resonance Imaging. 2014 32(2):107-17.

Kim, MS; Ryabets-Lienhard, A; Bali B; Lane, CJ; Park, AH; Hall, S; Geffner, ME. Decreased Adrenomedullary Function in Infants with Classical Congenital Adrenal Hyperplasia. Journal of Clinical Endocrinology and Metabolism. 2014 99: E1597–E1601.

Kim, MS; Ryabets-Lienhard, A; Geffner, ME. Management of Congenital Adrenal Hyperplasia in Childhood. Current Opinion in Endocrinology, Diabetes and Obesity. 2012 Dec; 19(6): 483-8.

Finkielstain, GP* and Kim, MS* (*joint 1st authorship); Sinaii, N; Nishitani, M; Van Ryzin, C; Hill, SC; Reynolds, JC; Hanna, RM; Merke, DP. Clinical Characteristics of a Cohort of 244 Patients with Congenital Adrenal Hyperplasia. Journal of Clinical Endocrinology and Metabolism. 2012 Dec;97(12):4429-38.

Gilsanz, V; Smith, ML; Goodarzian, F; Kim, M; Wren, TA; Hu, HH. Changes in Brown Adipose Tissue in Boys and Girls during Childhood and Puberty. Journal of Pediatrics. 2012 Apr;160(4):604-609. e1.

Chapter:

Kim MS, Tseng T, Koppin CM, Geffner ME. Congenital Adrenal Hyperplasia in the Adolescent. In: Shoupe D, ed. Handbook of Gynecology, 1st ed. Switzerland: Springer International Publishing; 2016 (online chapter); 2017 (e-book and print).

Kim MS, Donohoue PA. Adrenal Disorders (Chapter 5). In: Kappy MS, Allen DB, Geffner ME, eds. Pediatric Practice Endocrinology, 2nd ed. New York: McGraw-Hill Professional; August, 2014.

Research

Mimi Kim, MD, MSc, is interested in understanding obesity and adiposity in children and adolescents with Congenital Adrenal Hyperplasia (CAH), as these youth have an increased prevalence of obesity beyond normative pediatric populations. We are also interested in various stages of development in CAH youth, from infancy through puberty. We hope to inform prevention efforts and treatment of complications through a better understanding of pathophysiology of CAH and obesity. She and her team seek to apply novel imaging technology to answer important questions in childhood metabolism and obesity. Dr. Kim is the co-director of the Congenital Adrenal Hyperplasia (CAH) Clinic in the division of Endocrinology, Diabetes and Metabolism.

Visit the CAH-Adrenal Laboratory.

Funding

NIH K23 Mentored Patient-Oriented Research Career Development Award – Brain and Adipose Contributors to Food Seeking in Youth with Adrenal Hyperplasia
The James H. Zumberge Research and Innovation Fund - Individual Research Award Food-Seeking Behavior in Childhood Obesity
Keston Foundation Research Award – Using Artificial Intelligence to Explore Congenital Adrenal Hyperplasia
Abell Foundation
CARES Foundation
Adrenomedullary Function in Infants and Toddlers with Congenital Adrenal Hyperplasia
CHLA CTSI

Research Studies

NEAT (Neuroimaging: Emotions and Appetite Testing) Study

The NEAT Study is about obesity, appetite, emotions, and how the brain develops in children. The study team is looking for volunteer youth to participate who are either healthy or have a clinical condition called Congenital Adrenal Hyperplasia (CAH).

Effects of Androgen Excess on Lipid Distribution in Congenital Adrenal Hyperplasia

The aim of this project is to delineate androgen effects on regional adipose depots and ectopic fat non-invasively by magnetic resonance (MR)-based imaging techniques in youth with Congenital Adrenal Hyperplasia (CAH).

Safety and Efficacy of Crinecerfont (NBI-74788) in Adult Subjects with Classic Congenital Adrenal Hyperplasia

This study aims to evaluate the efficacy, safety, and tolerability of NBI-74788 versus placebo administered bid with breakfast and the evening meal (doses separated by approximately 12 hours) for 24 weeks in approximately 165 adult subjects with classic CAH due to 21-hydroxylase deficiency.

Neurocrine Ped Study

This is a Phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of crinecerfont versus placebo administered twice daily (bid) with breakfast and evening meals for28 weeks in approximately 81 pediatric subjects with classic congenital adrenal hyperplasia (CAH) due to21-hydroxylase deficiency.

Spruce Adult Study

This study will evaluate the potential of tildacerfont to reduce GC burden in adult subjects with classic CAH who have LLD ≤ A4 ≤ 2.5x ULN and are on supraphysiologic doses of GC therapy (≥30 mg/day and ≤60 mg/day HCe).

Diurnal Study

This study will compare the efficacy, safety and tolerability of twice daily Chronocort with twice daily IRHC (Cortef®) over a randomized treatment period of up to 52 weeks in participants aged 16 years and over with known classic CAH due to 21-hydroxylase deficiency. The primary efficacy assessment of biochemical responder rate and the key secondary assessments of dose responder rate and mean total daily dose will be assessed after 52 weeks of randomized treatment.

Food Choices in Type I Diabetes

Evaluate food choices in patients with Type 1 diabetes.

Best Starts in CAH (Congenital Adrenal Hyperplasia)

This study aims to measure and describe the amount and frequency of physical activity, feeding, and sleeping across days and months in infancy.

Food Choices in Type 2 Diabetes

Food Choices in patients with Type 2 Diabetes.

MRI of Congenital Adrenal Hyperplasia (CAH) Youth

Body Composition in Newborns with MRI of Congenital Adrenal Hyperplasia (CAH).

Natural History Study of Congenital Adrenal Hyperplasia (CAH) from Infancy

By reviewing the charts of CAH infants who come to our facility for treatment, we hope to discover which treatments, all of which are standard of care, lead to better outcomes for patients (primarily in the first year of life).

Adrenas CAH (Congenital Adrenal Hyperplasia) Study

This is a Phase 1/2, first-in-human, open-label, dose-escalation study designed to evaluate the safety, tolerability, and efficacy of BBP-631 administered to up to 25 adult participants diagnosed with classic congenital adrenal hyperplasia (CAH) (simple virilizing or salt-wasting, Group 1) or with classic salt-wasting CAH (Group 2) due to 21-hydroxylase deficiency (21-OHD) and who are monitored for 24 weeks post-treatment. All participants who receive BBP-631 will be followed for an additional 4.5 years for safety and efficacy in a separate long term follow up protocol (Study CAH-399). In total, all participants will be followed for at least 5 years after the date of treatment with BBP-631.