Research Focus
- Pediatric sarcomas driven by fusion oncogenes
- Germ cell tumors of the ovary and testis
- DICER1-related cancers including Wilms tumor of the kidney
Research Overview
Our lab’s primary research and clinical focus is on solid tumors that develop during childhood, including sarcomas, germ cell tumors and Wilms tumor. Our major goal is to conduct basic and translational research that reveals the molecular mechanisms driving these cancers, and that can lead to new and more effective therapies.
We use complementary approaches including human tumor genomics, animal models and small-molecule screening. We make extensive use of zebrafish genetic models for these studies, seeking to take advantage of the powerful genetics, developmental biology, imaging and small molecule screening that the zebrafish system affords.
