Yuhua Zheng, MD, MS
Yuhua Zheng, MD, graduated from Peking University Health Science Center, School of Medicine. She also obtained her Master of Science degree from Peking University Health Science Center. After finishing her residency training in pediatrics at Peking University First Hospital, Dr. Zheng came to the University of California, San Francisco, and as a research postdoctoral fellow conducted her basic science research on EDG signaling, a family of G-protein coupled receptors involved in wound healing. Dr. Zheng then finished her second residency training in pediatrics in the U.S. She received her pediatric gastroenterology fellowship training at Children’s Hospital Los Angeles, Division of Gastroenterology, Hepatology and Nutrition, Keck School of Medicine of USC. She received a National Institutes of Health K12 grant and focused her basic research on inflammatory bowel disease. Currently, Dr. Zheng serves as the Medical Director of CHLA’s Pancreas Program as well as the Director of her division’s International Education Program.
Dr. Zheng focuses on taking care of patients with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP) along with other pancreas disorders. Dr. Zheng is also interested in research on understanding inflammatory bowel disease.
Education
Peking University Health Science Center, School of Medicine
Peking University First Hospital
White Memorial Medical Center
Peking University First Hospital
White Memorial Medical Center
Children’s Hospital Los Angeles - Pediatric Gastroenterology
Accomplishments
Pediatric Gastroenterology - American Board of Pediatrics
General Pediatrics - American Board of Pediatrics
North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN)
American Gastroenterological Association (AGA)
Active Committee Member of Pancreas Committee of NASPGHAN
Former Committee Member of Inflammatory Bowel Disease Committee of NASPGHAN
International Association of Pancreatology
NIH K12
NIH NIDDK UO1
1. Pancreas disorders:
- Acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP)
- Autoimmune pancreatitis
- Annular pancreas
- Pancreas divisum
- Pancreatic cysts and pseudocysts
- Pancreatic tumors
- Pancreatic exocrine insufficiency
- Pancreatic trauma
2. Inflammatory bowel disease
3. Pediatric gastroenterology
Publications
An S, Zheng Y and Goetzl E. Recombinant Human G Protein-Coupled Lysophosphatidic Acid Receptors Mediate Intracellular Calcium Mobilization. Mol Pharmacol. 54(5):881-8,1998. PMID: 9804623
An S, Bleu T, Zheng Y. Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors. Mol Pharmacol. 1999 May;55(5):787-94. PMID: 10220556
An S, Zheng Y and Bleu T. Sphingosine 1-phosphate-induced cell proliferation, survival and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. J Biol Chem. 7;275(1):288-96, 2000. PMID: 10617617
Zheng Y, Voice J, Kong Y, Goetzl E. Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes. FASEB J. 14(15):2387-9, 2000. PMID: 11024010
Zheng, Y; Kong, Y; Goetzl, E. Lysophosphatidic acid receptor-selective effects on Jurka T cell migration through a Matrigel model basement membrane. J Immunol. 15;166(4):2317-22, 2001. PMID: 11160288
H Peng, L Dara, T Li, Y Zheng, H Yang, JM Mato, SC. Lu. MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer Hepatology. 2013 Jun;57(6):2299-313, PMID: 23325601 PMCID: PMC3642222
H Yang**, Y Zheng**, A Rojas, JM. Mato, and SC. Lu. Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells. J Biol Chem. 288(32):23161-70, 2013. PMID: 23814050 PMCID: PMC3743488
T W.H. Li, H Peng, H Yang, S Kurniawidjaja, P Panthaki, Y Zheng, J M. Mato, and S C. Lu. S-adenosylmethionine and Methylthioadenosine Inhibit Beta Catenin Signaling by Multiple Mechanisms in Liver and Colon Cancer Mol Pharmacol. 87(1):77-86, 2015. PMID: 25338671 PMCID: PMC4279083
Yuhua Zheng, Sonia Michail. EBV Status and Thiopurine Use in Children with Inflammatory. Bowel Disease (Expert Comment) Practice Update 2016 June Authors
Uc A, Perito ER, Pohl JF, Shah U, Abu-El-Haija M, Barth B, Bellin MD, Ellery KM, Fishman DS, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes RW, Husain SZ, Maqbool A, Mascarenhas MR, McFerron BA, Morinville VD, Lin TK, Liu QY, Nathan JD, Rhee SJ, Ooi CY, Sellers ZM, Schwarzenberg SJ, Serrano J, Troendle DM, Werlin SL, Wilschanski M, Zheng Y, Yuan Y, Lowe ME; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE2) Cohort Study in Consortium for the Study of chronic Pancreatitis, Diabetes and Pancreatic Cancer’s (CPDPC): Design and Rationale, Pancreas. 47(10):1222-1228, 2018. PMID: 30325861 PMCID: PMC6195325
Zheng Y, Fecal Microbiota Transplantation Indications and Protocol, Book Chapter 2019
D Xi**, Y Zheng*, Pediatric pancreatitis. Electronic Journal of Development Medicine. Invited review paper 2019
Emily R. Perito, Tonya M. Palermo, John F. Pohl, Maria Mascarenhas, Maisam Abu-El-Haija, Bradley Barth, Melena D. Bellin, Douglas S. Fishman, Steven Freedman, Cheryl Gariepy, Matthew Giefer, Tanja Gonska, Melvin B. Heyman, Ryan W. Himes, Sohail Z. Husain, Tom Lin, Quin Liu, Asim Maqbool, Brian McFerron, Veronique D. Morinville, Jaime D. Nathan, Chee Y. Ooi, Sue Rhee, Sarah Jane Schwarzenberg, Uzma Shah, David M. Troendle, Steven Werlin, Michael Wilchanski, Yuhua Zheng, M. Bridget Zimmerman, Mark Lowe, Aliye Uc, Factors Associated with Frequent Opioid Use in Children with Acute Recurrent and Chronic Pancreatitis. J Pediatr Gastroenterol Nutr. 70(1):106-114, 2020. PMID: 31567889 PMCID: PMC6934913
Palermo TM, Murray C, Aalfs H, Abu-El-Haija M, Barth B, Bellin MD, Ellery K, Fishman DS, Gariepy CE, Giefer MJ, Goday P, Gonska T, Heyman MB, Husain SZ, Lin TK, Liu QY, Mascarenhas MR, Maqbool A, McFerron B, Morinville VD, Nathan JD, Ooi CY, Perito ER, Pohl JF, Schwarzenberg SJ, Sellers ZM, Serrano J, Shah U, Troendle D, Zheng Y, Yuan Y, Lowe M, Uc; Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer. Web-based cognitive-behavioral intervention for pain in pediatric acute recurrent and chronic pancreatitis: Protocol of a multicenter randomized controlled trial from the study of chronic pancreatitis, diabetes and pancreatic cancer (CPDPC). Contemp Clin Trials. 88:105898, 2020. PMID: 31756383 PMCID: PMC6952537
Alka Goyal, Yuhua Zheng, Lindsey G. Albenberg, Natalie L. Stoner, Lara Hart, Razan Alkhouri, Kyle Hampson, Sabina Ali, Michele Cho-Dorado, Rakesh K. Goyal, Andrew Grossman. Anemia in Children with Inflammatory Bowel Disease: A Position Paper by the IBD Committee of the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition. JPGN 07/2020
Research
Dr. Zheng's primary research interest is pediatrics pancreas disorders. Dr. Zheng is the site primary investigator in multiple international studies including: The International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE and INSPPIRE2), Safety & Technical outcomes of ERCP in Pediatric Patients Performed by Adult vs Pediatric Gastroenterologists. Dr. Zheng was also the primary investigator in multiple multicenter, randomized, -blind, placebo-controlled studies of Anti-TNF agents used in inflammatory bowel disease.
Reasearch Topics
1. The International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE and INSPPIRE2)
2. Safety & Technical outcomes of ERCP in Pediatric Patients Performed by Adult vs Pediatric Gastroenterologists
3. Multiple multicenter, randomized, -blind, placebo-controlled studies of Anti-TNF agents used in inflammatory bowel disease.
4. Hepatitis B Antibody in Inflammatory Bowel Disease patients
Research Focus/Overview
To comprehensively characterize the pediatric population with Acute Recurrent Pancreatitis (ARP) and Chronic Pancreatitis (CP) and determine predictors of early onset CP and its sequelae.
Acute pancreatitis (AP) was once considered an uncommon disease of childhood. In recent years, the number of children with AP has increased to an annual incidence approaching that of adults. Despite modest incidence rates, ARP and CP are associated with significance disease burden. The risk factors that predispose children to recurrent attacks of AP, then progression from ARP to CP and finally to exocrine and endocrine pancreatic insufficiency are not known. Most of the existing information on diagnostic modalities and treatment options is derived from adult studies. Most studies on pediatric pancreatitis are retrospective. Therefore it is not possible to draw conclusions about pediatric ARP and CP from these studies. Also, the lack of patient data and understanding makes it impossible to design and implement therapeutic trials in children. Because ARP and CP are not common in pediatrics, prospective multicenter studies are crucial to address fundamental gaps in knowledge. There are no prospective studies, nor diagnostic and therapeutic guidelines in pediatric CP. The INSPPIRE Consortium was formed to systematically characterize ARP and CP in children and address the knowledge gap in pediatric pancreatitis. We plan to overcome these barriers using the collective expertise, data, and samples provided by all collaborating sites.
Study population and methodology: The study will enroll a total of 860 patients 0-18 y/o with ARP or CP over the next 4 years. Patient questionnaires and physician surveys will be applied at the time of enrollment and annually. We aim to define the demographics of the pediatric ARP and CP cohort, describe risk factors, presence of family history of acute and chronic pancreatitis, diabetes and pancreatic cancer and assess disease burden and sequelae.
Statistical considerations: Summary statistics and graphs will be used to characterize the pediatric population, disease course, and development of complications. Continuous variables will be summarized by mean, median, range, standard deviation and 95% confidence interval. Categorical variables will be summarized by frequency table and 95% confidence. All statistical analyses will be based on the combined data collected in this protocol and the previous protocol (i.e. INSPIRE 1) before the study team joined the CPDPC consortium.
Current Funding
NIH NIDDK subaward
Current Research Studies
1. The International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE and INSPPIRE2)
2. Safety & Technical outcomes of ERCP in Pediatric Patients Performed by Adult vs Pediatric Gastroenterologists
3. Multiple multicenter, randomized, -blind, placebo-controlled studies of Anti-TNF agents used in inflammatory bowel disease.
4. Hepatitis B Antibody in Inflammatory Bowel Disease patients
Research Studies
The purpose of the study is to collect information from children 0-18 years of age with all types of pancreatitis to determine the number of children diagnosed with this condition, understand the causes and progression of the disease, and review laboratory and imaging findings as well as responses to any treatments given.
