Borzage Lab: Media

Links to Media Coverage

Dr. Matthew Borzage, a researcher at Children’s Hospital Los Angeles, collaborated on a groundbreaking international project to develop comprehensive growth charts for brain development. Published in Nature, this effort integrated data from over 100,000 brain scans across the lifespan—from 16 weeks post-conception to 100 years old—to provide unprecedented insights into how the brain grows and changes. The charts reveal key milestones in gray and white matter development and highlight a previously unknown rapid growth phase in early childhood. While not yet ready for clinical use, these charts lay the foundation for future neuroscientific research and clinical applications.

Studying Anesthesia’s Impact on the Developing Brain | Children's Hospital Los Angeles (chla.org)

Researchers Conduct First-of-Its-Kind Review of Anesthesia Exposure’s Impact on Childhood Brain Development

CHLA Researchers Conduct First-of-Its-Kind Review of Anesthesia Exposure’s Impact on Childhood Brain Development | Children's Hospital Los Angeles

Dr. Matthew Borzage and Dr. Bradley Peterson from Children’s Hospital Los Angeles conducted a comprehensive review of anesthesia research, highlighting concerns about its potential long-term effects on children's brain development. Their analysis, encompassing 131 studies from in vitro to clinical trials, suggests that anesthesia exposure, especially multiple times at a young age, may lead to cognitive and behavioral issues later in life. The review underscores the need for further research to clarify risks and guide clinical practices to balance the benefits of anesthesia with its potential neurological impacts on pediatric patients. The study was published in Anesthesia & Analgesia.

USC launches large-scale study of dementia and diabetes in adults with Hispanic ancestry

The Keck School of Medicine of USC has initiated a comprehensive study funded by a $3.7 million grant from the National Institute on Aging to investigate the connection between type 2 diabetes and dementia in adults of Hispanic ancestry. Led by a multidisciplinary team, the research aims to uncover the biological mechanisms underlying the increased risk of dementia among individuals with diabetes, utilizing advanced imaging technologies and cognitive assessments over a five-year period. This initiative seeks to address significant health disparities and expand understanding in a population historically underrepresented in research.

Research Faculty Spotlight: Matthew Borzage, PhD | Children's Hospital Los Angeles (chla.org)

Dr. Matthew Borzage, a biomedical engineer at CHLA, specializes in using MRI to study how conditions affect the brain's blood vessels and metabolism. His primary focus is investigating the potential neurotoxic effects of anesthesia on the developing brain, supported by a National Institutes of Health grant. Dr. Borzage emphasizes collaborative research and mentoring, highlighting his dedication to both advancing science and supporting his team.