Schumacher Gut Science Lab: Publications

Publications on PubMed

Schumacher MA, Thai MH, Hsieh JJ, Gramajo A, Liu CY, Frey MR. Wnt/β-catenin maintains epithelial IL-33 in the colonic stem and progenitor cell niche and drives its induction in colitis. Mucosal Immunol. 2025 Feb;18(1):248-256. doi: 10.1016/j.mucimm.2024.11.007. Epub 2024 Nov 24. PubMed PMID: 39592069; PubMed Central PMCID: PMC11895084.

Bhesania N, Schumacher MA. Augmenting anti-inflammatory macrophage function in colitis: a neuroimmune mechanism to drive intestinal wound repair. Am J Physiol Gastrointest Liver Physiol. 2025 Feb 1;328(2):G94-G95. doi: 10.1152/ajpgi.00368.2024. Epub 2024 Dec 23. PubMed PMID: 39716372.

Eshleman EM, Rice T, Potter C, Waddell A, Hashimoto-Hill S, Woo V, Field S, Engleman L, Lim HW, Schumacher MA, Frey MR, Denson LA, Finkelman FD, Alenghat T. Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity. Immunity. 2024 Feb 13;57(2):319-332.e6. doi: 10.1016/j.immuni.2024.01.002. Epub 2024 Jan 30. PubMed PMID: 38295798; PubMed Central PMCID: PMC10901458.

Schumacher MA. The emerging roles of deep crypt secretory cells in colonic physiology. Am J Physiol Gastrointest Liver Physiol. 2023 Dec 1;325(6):G493-G500. PMID: 37697924.

Schumacher MA, Liu CY, Katada K, Thai MH, Hsieh JJ, Hansten BJ, Waddell A, Rosen MJ, Frey MR. Deep Crypt Secretory Cell Differentiation in the Colonic Epithelium Is Regulated by Sprouty2 and Interleukin 13. Cell Mol Gastroenterol Hepatol. 2023;15(4):971-984. PMID: 36414210.

Schumacher MA, Hsieh JJ, Liu CY, Appel KL, Waddell A, Almohazey D, Katada K, Bernard JK, Bucar EB, Gadeock S, Maselli KM, Washington MK, Grikscheit TC, Warburton D, Rosen MJ, Frey MR. Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33. Nat Commun. 2021 Feb 5;12(1):836. PMID: 33547321.