Publications
Publications are up to date at https://profiles.scctsi.org/tamara.simon
CLIMB
Hodor P, Pope CE, Whitlock KB, McDonald PJ, Hauptman J, Hoffman LR, Limbrick DD Jr, Simon TD on behalf of the Cerebrospinal FLuId MicroBiota in Shunts (CLIMB) Study Group. A search for bacteria identified from cerebrospinal fluid shunt infections in previous surgical events. PLoS One. 2024 Oct 10;19(10):e0311605. doi: 10.1371/journal.pone.0311605. eCollection 2024. PMID: 39388396.
Simon TD, Schaffzin JK, Podkovik S, Hodor P. Cerebrospinal Fluid Shunt Infections. Infect Dis Clin North Am. 2024 Dec; 38(4)757-775. doi: 10.1016/j.idc.2024.07.008. Epub 2024 Sep 12. PMID: 39271303. Review. Role in study: conceptualization, drafting paper for content.
Simon TD, Sedano S, Rosenberg-Hasson Y, Durazo-Arvizu R, Whitlock KB, Hodor P, Hauptman JS, Limbrick DD, McDonald P, Ojemann JG, Maecker HT; Cerebrospinal FLuId MicroBiota in Shunts CLIMB Study Group. Lower levels of Th1 and Th2 cytokines in cerebrospinal fluid (CSF) at the time of initial CSF shunt placement in children are associated with subsequent shunt revision surgeries. Cytokine. 2023 Sep;169:156310. doi: 10.1016/j.cyto.2023.156310. Epub 2023 Jul 29. PMID: 37523803; PMCID: PMC10528342.
Pandey S, Whitlock KB, Test MR, Hodor P, Pope CE, Limbrick DD Jr, McDonald PJ, Hauptman JS, Hoffman LR, Simon TD; Cerebrospinal FLuId MicroBiota in Shunts (CLIMB) Study Group. Characterization of cerebrospinal fluid (CSF) microbiota at the time of initial surgical intervention for children with hydrocephalus. PLoS One. 2023 Jun 21;18(6):e0280682. doi: 10.1371/journal.pone.0280682. PMID: 37342995; PMCID: PMC10284395.
Simon TD, Sedano S, Rosenberg-Hasson Y, Durazo-Arvizu R, Whitlock KB, Hodor P, Hauptman JS, Limbrick DD, McDonald P, Ojemann JG, Maecker HT; Cerebrospinal FLuId MicroBiota in Shunts CLIMB Study Group. Lower levels of Th1 and Th2 cytokines in cerebrospinal fluid (CSF) at the time of initial CSF shunt placement in children are associated with subsequent shunt revision surgeries. Cytokine. 2023 Sep;169:156310. doi: 10.1016/j.cyto.2023.156310. Epub 2023 Jul 29. PMID: 37523803.
Pope CE, Whitlock KB, Hodor P, Limbrick DD Jr, McDonald PJ, Hauptman J, Hoffman LR, Simon TD. A Refined, Controlled 16S rRNA Gene Sequencing Approach Reveals Limited Detection of Cerebrospinal Fluid Microbiota in Children with Bacterial Meningitis. Microbiol Spectr. 2023 Jun 15;11(3):e0036123. doi: 10.1128/spectrum.00361-23. Epub 2023 May 4. PMID: 37140368; PMCID: PMC10269467.
Simon TD, Schaffzin JK, Stevenson CB, Willebrand K, Parsek M, Hoffman LR. Cerebrospinal fluid shunt infection: Emerging paradigms in pathogenesis that affect prevention and treatment. J Pediatr. 2019 Mar;206:13-19. doi: 10.1016/j.jpeds.2018.11.026. Epub 2018 Dec 6. PMID: 30528757; PMCID: PMC6389391.
Hodor P, Pope CE, Whitlock KB, Hoffman LR, Limbrick DL, McDonald PJ, Hauptman JS, Ojemann JG, Simon TD. Molecular characterization of microbiota in cerebrospinal fluid from patients with CSF shunt infections using whole genome amplification followed by shotgun sequencing. Front Cell Infect Microbiol. 2021 Aug 20;11:699506. doi: 10.3389/fcimb.2021.699506. PMID: 34490140; PMCID: PMC8417900.
Whitlock KB, Pope CE, Hodor P, Hoffman LR, Limbrick DL Jr, McDonald PJ, Hauptman JS, Ojemann JG, Simon TD; Cerebrospinal fLuId MicroBiota in Shunts Study (CLIMB) Group. Characterization of cerebrospinal fluid (CSF) microbiota from patients with CSF shunt infection and reinfection using high throughput sequencing of 16S ribosomal RNA genes. PLoS One. 2021 Jan 6;16(1):e0244643. doi: 10.1371/journal.pone.0244643. PMID: 33406142; PMCID: PMC7787469.
PHIS+ Shunt Infection Prevention
Simon TD, Hayati Rezvan P, Coffin SE, Hall M, Hauptman JS, Kronman MP, Mangano FT, Podkovik S, Pollack IF, Schaffzin JK, Thorell E, Warf BC, Zhou C, Whitlock KB. Infection rates during eras of intrathecal antibiotic use followed by antibiotic-impregnated catheter use in prevention of cerebrospinal fluid shunt infection. J Neurosurg Pediatr. 2024 Jul 19:1-8. doi: 10.3171/2024.5.PEDS23372. Epub ahead of print. PMID: 39029119.
Podkovik S, Zhou C, Coffin SE, Hall M, Hauptman JS, Kronman MP, Mangano FT, Pollack IF, Sedano S, Vega J, Schaffzin JK, Thorell E, Warf BC, Whitlock KB, Simon TD. Antibiotic impregnated catheters and intrathecal antibiotics for CSF shunt infection prevention in children undergoing low-risk CSF shunt surgery. BMC Pediatr. 2024 May 11;24(1):325. doi: 10.1186/s12887-024-04798-9. PMID: 38734598; PMCID: PMC11088062.
Podkovik S, Zhou C, Coffin SE, Hall M, Hauptman JS, Kronman MP, Mangano FT, Pollack IF, Sedano S, Schaffzin JK, Thorell E, Warf BC, Whitlock KB, Simon TD. Utilization trends in cerebrospinal fluid shunt infection prevention techniques in the United States from 2007 to 2015. J Neurosurg Pediatr. 2024 Jan 5:1-10. doi: 10.3171/2023.11.PEDS2337. Epub ahead of print. PMID: 38181501; PMCID: PMC10810681.
Sedano S, Kronman MP, Whitlock KB, Zhou C, Coffin SE, Hauptman JS, Heller E, Mangano FT, Pollack IF, Schaffzin JK, Thorell E, Warf BC, Simon TD. Associations of standard care, intrathecal antibiotics, and antibiotic impregnated catheters with cerebrospinal fluid shunt infection organisms and resistance. J Pediatric Infect Dis Soc. 2023 Sep 8:piad064. doi: 10.1093/jpids/piad064. Epub ahead of print. PMID: 37681670.
