To test the effectiveness of an addiction-based weight loss intervention, embodied first as a smartphone app with telephone coaching (AppCoach) compared to (1) addiction model based weight-loss app alone (App) and (2) multi-disciplinary in-clinic weight loss intervention (Clinic) on weight outcomes of overweight and obese adolescents at 3, 6, 12 and 18 months post enrollment.

This research is being done to test the safety and effectiveness of intranasal carbetocin to treat Prader Willi Syndrome.

To find out if Time-Limited Eating can help teens lose weight.