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Functional Human Tissue-Engineered Liver Generated from Stem and Progenitor Cells

August 30, 2016

A research team led by investigators at The Saban Research Institute of Children’s Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor

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Tissue Engineering: The Big Picture on Growing Small Intestines

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Babies born prematurely often face intense medical challenges, including intestines that are underdeveloped or diseased. While an intestine transplant can benefit some patients, many babies are simply

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New Clues to Kidney Cell Renewal

September 14, 2016

In a first-of-its-kind look at human kidney development, researchers at The Saban Research Institute of Children’s Hospital Los Angeles have isolated human nephron progenitor (NP) cells. Their results

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Research and Breakthroughs

Baby’s Breath: A New Way to Study Neonatal Lung Disease

February 16, 2016

Normal lung (image A) compared to lung developed with low levels of VEGF (image B) demonstrating abnormal air spaces and lung tissue. Photo courtesy of Grikscheit Lab, The Saban Research Institute of

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What Is Necrotizing Enterocolitis?

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Early treatment can help overcome this life-threatening condition in premature infants.

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Necrotizing Enterocolitis in Preterm Infants

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Clinical Scenario A 21-day-old male infant born at 26 week’s gestation and birth weight 860 grams, currently on CPAP for respiratory distress syndrome, develops abdominal distention and green-colored

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Research and Breakthroughs

New Approach to Modeling Ewing Sarcoma Leads to a Novel Discovery

April 19, 2022

A new study from Children’s Hospital Los Angeles found that a specific pathway may be driving tumor growth in Ewing sarcoma.

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Presentations Showcase Latest Pediatric GI Research

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Children’s Hospital Los Angeles faculty share new findings on transnasal esophagoscopy, fatty liver disease screening and the role of Malrd1.

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Research and Breakthroughs

Bone Loss Associated With Leukemia Therapy Occurs Sooner Than Previously Thought

February 12, 2016

Patients with acute lymphoblastic leukemia are at increased risk for bone fractures due to bone loss resulting from treatment. This decrease in bone density (as illustrated here) can occur as soon as

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