The Strategic Therapies for Overcoming Reactive Immunology (STORM) lab investigates the genetic origins of neuroinflammation in rare pediatric diseases. Our work focuses, in particular, on Down syndrome and the role of neuroinflammation in the development of related neurologic conditions such as cerebrovascular disease (Moyamoya syndrome), epilepsy, Alzheimer’s disease, and emerging neuropsychiatric conditions such as Down syndrome regression disorder (DSRD). Our research also extends to rare genetic disorders including leukodystrophy and Aicardi-Goutieres syndrome. In addition, our large neuroimmunology program is involved with a variety of pediatric-onset inflammatory disorders such as multiple sclerosis (MS), myelin oligodendrocyte glycoprotein-associated disease (MOGAD), and autoimmune encephalitis (AE).
The STORM lab is at the forefront of pediatric neuroimmunology research, hosting a variety of translational neuroscience studies, housing the largest pediatric cerebrospinal fluid (CSF) biorepository on the West Coast, and conducting the first clinical trial for DSRD. Our international collaborations in neurologic conditions in Down syndrome, MOGAD, and leukodystrophies allow us to be uniquely linked with cutting-edge research around the world. Through this pioneering work, our lab aims to uncover the mechanisms behind neuroinflammatory disorders and advance our understanding to inform therapeutic intervention and optimize each patient's treatment.
Mission Statement
At the STORM lab, our mission is to prevent neurologic diseases caused by inflammation in children with rare neurogenetic disorders. We spearhead research that bridges the gap between genetics, immunology, and neurology to develop innovative therapies targeting the unique conditions these vulnerable populations face. Our commitment is to transform scientific discoveries into tangible solutions that enhance the quality of life for affected children and their families, driving forward a future where every child can thrive.
Collaborate With Us
Research Participants
At CHLA, research is for everyone. Whether this is your first time considering research or you have done it many times before, our team is dedicated to making you and your child’s experience smooth and hassle free.
If you are interested in participating in one of our research studies, please contact us at dsresearch@chla.usc.edu.
Get Involved! Work with Us!
Our lab is constantly growing. If you are interested in joining our research team, please forward a copy of your cover letter and CV to dsresearch@chla.usc.edu. Available positions are listed below:
- Clinical Research Assistant (1)
- Post-doctoral fellow in translational neuroimmunology (1)
- Clinical Lab Specialist (1)
- Program Manager (1)
Learn with Us!
For undergraduates, medical students, or visiting trainees, we sponsor both short and long-term research projects. If you are interested in working with us, please e-mail a CV and statement of purpose to dsresearch@chla.usc.edu.
Neurology residents interested in a clinical fellowship in neuroimmunology can reach out to Dr. Santoro directly via the dsresearch@chla.usc.edu e-mail address. Clinical fellowships are offered through the San Francisco Match on an annual basis. Additional information can be located at SF Match.
Neurology residents interested in a research fellowship in neuroimmunology can reach out to Dr. Santoro directly via the dsresearch@chla.usc.edu e-mail address. Research fellowships are offered outside of the San Francisco Match and are contingent on funding availability.
Raise Money with Us!
Each year, the STORM lab runs multiple fundraisers with the goal of raising money to support research operations. If you are interested in donating, hosting a local fundraiser or want to help support our team in other ways, please do not hesitate to reach out.
Collaborate with Us!
The STORM lab has collaborations all over the country and world. Research strength is driven through close collaborations with other academic and community partners. If you are interested in a potential collaboration, please e-mail us at dsresearch@chla.usc.edu.
